Permeation of Nicotinamide Mononucleotide (NMN) in an Artificial Membrane as a Cosmetic Skin Permeability Test Model

Plain-language summary

Published 2025 in J Cosmet Dermatol, this work by Betsuno R and collaborators tackles a specific question within benefits-focused NMN/NAD+ research.

Key findings reported by the authors

• Mechanistic study in J Cosmet Dermatol (2025) on NAD+/sirtuin/longevity biology
• Adds to the foundational literature underlying NMN supplementation rationale
• First author: Betsuno R

What this means for Malaysian buyers

For readers in Malaysia weighing whether to start or continue NMN supplementation, this paper sits at the limited end of the evidence spectrum. Limited-tier evidence (mouse, in-vitro, or single small pilot) is hypothesis-generating only; do not extrapolate dosing or efficacy claims to humans without supporting replication. Findings here are most directly relevant to benefits decisions, with secondary relevance to science. Our editorial methodology weights human placebo-controlled trials above mouse mechanistic work above review articles.