NMN for Age-Related Fatigue: What the Evidence Actually Shows

Category: longevity | ICD-10: R53.83 | Evidence tier: preliminary-human

What is Age-Related Fatigue?

Age-related fatigue is persistent low energy and reduced exercise tolerance that comes with ageing, after excluding anaemia, thyroid issues and depression.

NMN relevance: the published evidence

Liao 2021 in amateur runners and Igarashi 2022 in older men reported small improvements in aerobic capacity or perceived energy. The effects are modest and the trials small. Sleep, iron status and exercise screening should be addressed first.

Questions to ask before supplementing

250-300 mg/day in published trials.

Contraindications and red flags

Persistent fatigue requires medical workup; do not mask it with supplements.

Bottom line for Malaysian patients

NMN is not registered with NPRA as a treatment for any specific condition; it is sold as a general health supplement. If you have age-related fatigue, use this page as a question list for a registered medical practitioner before adding NMN to existing therapy. Read our safety guide for full red-flag context.

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