Dr. Junichiro Irie
Lecturer, Department of Internal Medicine | Keio University School of Medicine
About
Japanese clinical researcher who published an early human NMN safety study in healthy Japanese men. Single-dose 100-500mg NMN was reported as tolerated in that small study.
Key contributions
- Early Japanese NMN safety trial
- Single-dose pharmacokinetic data
- Asian-population dosing baseline
Publications in our knowledge base (3)
Every paper below is cited at least once across NMN Malaysia articles. Click any title to read the source on PubMed/DOI and see the cluster of articles that depend on its findings.
- Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men
- Mechanistic study in Endocr J (2024) on NAD+/sirtuin/longevity biology
- Adds to the foundational literature underlying NMN supplementation rationale
- First author: Yamaguchi S
- Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men
- Single oral doses of 100, 250, 500 mg NMN tolerated without adverse events in 10 men
- Plasma NMN metabolites rose dose-dependently
- First Japanese human safety study
- NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
- Authoritative comparison of NMN and NR mechanisms
- Tissue distribution and pharmacokinetics
- Most-cited NMN vs NR review
Why their work matters for Malaysian buyers
Dr. Junichiro Irie's research forms part of the evidence base we use to evaluate NMN and NR products available in Malaysia. When we make claims about dose ranges, safety, mechanism, or efficacy on this site, those claims trace back through papers like the ones above. The Malaysian regulatory framework (NPRA notification, JAKIM halal certification) does not perform efficacy review on supplements - buyers must do their own evidence weighting. Researcher profiles help you verify that the underlying science is robust, not just marketing.
How we cite this work
Every NMN Malaysia article that depends on findings from Dr. Junichiro Irie's lab carries an inline citation linking to a structured PubMed entry. You can verify any claim by clicking the citation and reading the source. This cited-research model is the bedrock of our editorial policy - see the 4-step review process for how we handle every health claim.
Related researchers
Browse other profiles: David Sinclair | Shinichiro Imai | Jun Yoshino | Charles Brenner | all profiles.