NMN/NAD+ Researcher Profiles

Profiles of 10 researchers shaping the NMN, NR, and NAD+ field - Sinclair, Imai, Yoshino, Trammell, Brenner, and others. Their key contributions and cited papers.

• Prof. David Sinclair

  Harvard Medical School

  Australian biologist whose lab helped clarify sirtuin biology and the role of NAD+ in aging. He founded Sirtris Pharmaceuticals (acquired by GSK) and co-authored Lifespan (2019), a...

• Prof. Shinichiro Imai

  Washington University School of Medicine

  Japanese researcher whose work with Leonard Guarente helped define the NAD+/sirtuin aging framework. Their 2014 review is a major conceptual source for why NMN became interesting a...

• Dr. Jun Yoshino

  Washington University School of Medicine

  Lead author of Yoshino et al. 2021 (Science), a placebo-controlled human NMN trial in postmenopausal women with prediabetes. The trial reported improved muscle insulin sensitivity ...

• Dr. Junichiro Irie

  Keio University School of Medicine

  Japanese clinical researcher who published an early human NMN safety study in healthy Japanese men. Single-dose 100-500mg NMN was reported as tolerated in that small study....

• Dr. Kenya Igarashi

  Tohoku University Graduate School of Medicine

  Lead author of Igarashi 2022, a placebo-controlled NMN trial in older Japanese men. The study reported changes in grip strength and walking speed after 250mg/day NMN over 12 weeks,...

• Prof. Charles Brenner

  City of Hope National Medical Center

  American biochemist who co-discovered nicotinamide riboside (NR) as a NAD+ precursor in 2004. Founded the field of NR research and later joined ChromaDex as Chief Scientific Adviso...

• Dr. Samuel Trammell

  University of Iowa

  Lead author of Trammell 2016 - the foundational NR pharmacokinetics paper. Demonstrated NR's bioavailability and dose-response NAD+ elevation in humans at 100, 300, and 1000mg. The...

• Prof. Johan Auwerx

  École Polytechnique Fédérale de Lausanne (EPFL)

  Belgian researcher whose lab demonstrated mitochondrial unfolded protein response and NAD+ regulation in aging. His group's work on urolithin A - a postbiotic NAD+ pathway modulato...

• Prof. Evandro Fei Fang

  University of Oslo

  Chinese-Norwegian researcher leading NAD+ research for neurodegenerative disease and brain aging. His Cell Metabolism reviews on NAD+ in brain aging and Alzheimer's set the framewo...

• Editorial Note: Malaysian researchers

  Various institutions

  As of 2026, Malaysian primary NMN clinical research is limited - most cited human trials originate from US, Japan, China, and Europe. Malaysian-led work on NAD+ biology comes prima...