NAD+ and sirtuins in aging and disease

Imai SI, Guarente L | Trends in Cell Biology | 2014 | Evidence: strong

Plain-language summary

Published 2014 in Trends in Cell Biology, this work by Imai SI and collaborators tackles a specific question within science-focused NMN/NAD+ research.

Key findings reported by the authors

Foundational review on sirtuin/NAD+ biology underlying NMN rationale
NAD+ decline with age framework
Imai's lab original framework

What this means for Malaysian buyers

For readers in Malaysia weighing whether to start or continue NMN supplementation, this paper sits at the strong end of the evidence spectrum. Strong-tier human placebo-controlled trial data carries the most weight in our editorial framework - treat findings as actionable signal, but always pair with at least one replication. Findings here are most directly relevant to science decisions. Our editorial methodology weights human placebo-controlled trials above mouse mechanistic work above review articles.

Where we cite this paper

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